Search results for "PHOSPHATIDYLCHOLINE HEADGROUP"

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Inverse Conformational Selection in Lipid–Protein Binding

2021

International audience; Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly used, for example, in carriers of mRNA vaccines. The outward-facing components of cellular membranes and lipid nanoparticles, the lipid headgroups, regulate membrane interactions with approaching substances, such as proteins, drugs, RNA, or viruses. Because lipid headgroup conformational ensembles have not been experimentally determined in physiologically relevant conditions, an essential question about their interactions with other biomolecules remains unanswered: Do headgroups excha…

DYNAMICSELECTRIC CHARGEBILAYERSPHOSPHATIDYLCHOLINE HEADGROUPMembrane lipidsDEUTERIUMPlasma protein bindingMolecular Dynamics Simulationlipidit010402 general chemistry01 natural sciencesBiochemistrybiomolekyylitCatalysis03 medical and health sciencesMolecular dynamicskemialliset sidoksetColloid and Surface ChemistryProtein structurePHOSPHOLIPID-BINDINGMAGNETIC-RESONANCE[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologySEGMENTAL ORDER[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyConformational ensemblesNuclear Magnetic Resonance Biomolecular030304 developmental biologychemistry.chemical_classification0303 health sciencesChemistryBiomoleculeMEMBRANE-LIPIDSProteinsPhosphatidylglycerolsGeneral Chemistrycomputer.file_formatProtein Data BankLipids0104 chemical sciencesBiophysicsPhospholipid BindingPhosphatidylcholinesMAS NMR1182 Biochemistry cell and molecular biologylipids (amino acids peptides and proteins)proteiinitcomputerProtein Binding

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